Discount airline JetBlue already currently flies non-stop Boston flights to San Diego, but starting April 7, American Airlines intends to resume daily San Diego flights from Boston (BOS).
On May 2, Delta/Northwest will be boarding daily Memphis flights to San Diego. Memphis is a significant hub for Delta/Northwest.
Discount airline AirTran brings back non-stop San Diego flights to Atlanta (ATL) starting May 5, with a single daily departure. On May 21, the AirTran intends to go double-daily on the route and also launch San Diego flights to Milwaukee (MKE).
On June 1, WestJet joins the San Diego line-up offering Calgary flights to San Diego three times a week.
Watch for seat sales, cheap San Diego flights and more, and check with the individual airlines for booking tickets.